MEMO1 protein (Canis lupus familiaris) - STRING interaction network

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Score

MEMO1

Mediator of cell motility 1. (280 aa)

Predicted Functional Partners:

SLC14A2

0.671

MACO1

0.655

ERBB2

0.591

CAMSAP2

0.563

KMO

0.560

DPY30

0.558

RPS8

0.552

ERBB4

0.545

RHOA

0.541

ERBB3

0.534

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAMSAP2	MEMO1	ENSCAFP00000044228	ENSCAFP00000008531	Calmodulin regulated spectrin associated protein family member 2.	Mediator of cell motility 1.	0.563
DPY30	MEMO1	ENSCAFP00000008539	ENSCAFP00000008531	Dpy-30 histone methyltransferase complex regulatory subunit.	Mediator of cell motility 1.	0.558
ERBB2	ERBB3	ENSCAFP00000024079	ENSCAFP00000000139	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Erb-b2 receptor tyrosine kinase 3.	0.998
ERBB2	ERBB4	ENSCAFP00000024079	ENSCAFP00000048210	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.991
ERBB2	MEMO1	ENSCAFP00000024079	ENSCAFP00000008531	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Mediator of cell motility 1.	0.591
ERBB2	RHOA	ENSCAFP00000024079	ENSCAFP00000030438	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]	0.609
ERBB3	ERBB2	ENSCAFP00000000139	ENSCAFP00000024079	Erb-b2 receptor tyrosine kinase 3.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.998
ERBB3	ERBB4	ENSCAFP00000000139	ENSCAFP00000048210	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.970
ERBB3	MEMO1	ENSCAFP00000000139	ENSCAFP00000008531	Erb-b2 receptor tyrosine kinase 3.	Mediator of cell motility 1.	0.534
ERBB3	RHOA	ENSCAFP00000000139	ENSCAFP00000030438	Erb-b2 receptor tyrosine kinase 3.	Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]	0.578
ERBB4	ERBB2	ENSCAFP00000048210	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.991
ERBB4	ERBB3	ENSCAFP00000048210	ENSCAFP00000000139	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.970
ERBB4	MEMO1	ENSCAFP00000048210	ENSCAFP00000008531	Receptor protein-tyrosine kinase.	Mediator of cell motility 1.	0.545
ERBB4	RHOA	ENSCAFP00000048210	ENSCAFP00000030438	Receptor protein-tyrosine kinase.	Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]	0.578
KMO	MEMO1	ENSCAFP00000023107	ENSCAFP00000008531	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	Mediator of cell motility 1.	0.560
MACO1	MEMO1	ENSCAFP00000018853	ENSCAFP00000008531	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	Mediator of cell motility 1.	0.655
MEMO1	CAMSAP2	ENSCAFP00000008531	ENSCAFP00000044228	Mediator of cell motility 1.	Calmodulin regulated spectrin associated protein family member 2.	0.563
MEMO1	DPY30	ENSCAFP00000008531	ENSCAFP00000008539	Mediator of cell motility 1.	Dpy-30 histone methyltransferase complex regulatory subunit.	0.558
MEMO1	ERBB2	ENSCAFP00000008531	ENSCAFP00000024079	Mediator of cell motility 1.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.591
MEMO1	ERBB3	ENSCAFP00000008531	ENSCAFP00000000139	Mediator of cell motility 1.	Erb-b2 receptor tyrosine kinase 3.	0.534