NRG2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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[Homology]

Score

NRG2

Neuregulin 2. (868 aa)

Predicted Functional Partners:

ERBB3

0.997

ERBB4

0.993

EGFR

0.992

ERBB2

0.989

ENSCAFP00000063426

0.970

NRG1

0.937

EREG

0.773

EPGN

0.740

AREG

0.638

HBEGF

0.638

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	EGFR	ENSCAFP00000039479	ENSCAFP00000005164	Amphiregulin.	Receptor protein-tyrosine kinase.	0.997
AREG	ENSCAFP00000063426	ENSCAFP00000039479	ENSCAFP00000063426	Amphiregulin.	Uncharacterized protein.	0.415
AREG	EPGN	ENSCAFP00000039479	ENSCAFP00000004566	Amphiregulin.	Epithelial mitogen.	0.819
AREG	ERBB2	ENSCAFP00000039479	ENSCAFP00000024079	Amphiregulin.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.937
AREG	ERBB3	ENSCAFP00000039479	ENSCAFP00000000139	Amphiregulin.	Erb-b2 receptor tyrosine kinase 3.	0.947
AREG	ERBB4	ENSCAFP00000039479	ENSCAFP00000048210	Amphiregulin.	Receptor protein-tyrosine kinase.	0.968
AREG	EREG	ENSCAFP00000039479	ENSCAFP00000038777	Amphiregulin.	Epiregulin.	0.973
AREG	HBEGF	ENSCAFP00000039479	ENSCAFP00000051029	Amphiregulin.	Heparin binding EGF like growth factor.	0.616
AREG	NRG1	ENSCAFP00000039479	ENSCAFP00000009552	Amphiregulin.	Neuregulin 1.	0.580
AREG	NRG2	ENSCAFP00000039479	ENSCAFP00000008572	Amphiregulin.	Neuregulin 2.	0.638
EGFR	AREG	ENSCAFP00000005164	ENSCAFP00000039479	Receptor protein-tyrosine kinase.	Amphiregulin.	0.997
EGFR	ENSCAFP00000063426	ENSCAFP00000005164	ENSCAFP00000063426	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.949
EGFR	EPGN	ENSCAFP00000005164	ENSCAFP00000004566	Receptor protein-tyrosine kinase.	Epithelial mitogen.	0.964
EGFR	ERBB2	ENSCAFP00000005164	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.994
EGFR	ERBB3	ENSCAFP00000005164	ENSCAFP00000000139	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.983
EGFR	ERBB4	ENSCAFP00000005164	ENSCAFP00000048210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.966
EGFR	EREG	ENSCAFP00000005164	ENSCAFP00000038777	Receptor protein-tyrosine kinase.	Epiregulin.	0.994
EGFR	HBEGF	ENSCAFP00000005164	ENSCAFP00000051029	Receptor protein-tyrosine kinase.	Heparin binding EGF like growth factor.	0.999
EGFR	NRG1	ENSCAFP00000005164	ENSCAFP00000009552	Receptor protein-tyrosine kinase.	Neuregulin 1.	0.994
EGFR	NRG2	ENSCAFP00000005164	ENSCAFP00000008572	Receptor protein-tyrosine kinase.	Neuregulin 2.	0.992