STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NR1D2Nuclear receptor subfamily 1 group D member 2. (576 aa)    
Predicted Functional Partners:
CRY1
Cryptochrome circadian regulator 1.
   
 0.974
ARNTL
Aryl hydrocarbon receptor nuclear translocator like.
    
 0.968
CRY2
Cryptochrome circadian regulator 2.
   
 0.957
DBP
D-box binding PAR bZIP transcription factor.
   
 0.942
NR1D1
Nuclear receptor subfamily 1 group D member 1.
   
 0.940
NCOR1
Nuclear receptor corepressor 1.
   
 0.938
CLOCK
Clock circadian regulator.
    
 0.910
NFIL3
Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]
   
 0.908
ENSCAFP00000058303
BZIP domain-containing protein.
   
 0.891
NPAS2
Neuronal PAS domain protein 2.
    
 0.869
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.