MYF5 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MYF5

Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (506 aa)

Predicted Functional Partners:

PAX7

0.939

PAX3

0.927

MSTN

0.793

MEF2C

0.750

EP300

0.747

ID1

0.725

MYH3

0.723

CREBBP

0.697

MEF2A

0.683

PRDM16

0.666

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	EP300	ENSCAFP00000036447	ENSCAFP00000001585	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	MEF2A	ENSCAFP00000036447	ENSCAFP00000046375	CREB binding protein.	Myocyte enhancer factor 2A.	0.554
CREBBP	MEF2C	ENSCAFP00000036447	ENSCAFP00000053374	CREB binding protein.	Myocyte enhancer factor 2C.	0.730
CREBBP	MYF5	ENSCAFP00000036447	ENSCAFP00000008695	CREB binding protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.697
EP300	CREBBP	ENSCAFP00000001585	ENSCAFP00000036447	E1A binding protein p300.	CREB binding protein.	0.999
EP300	MEF2A	ENSCAFP00000001585	ENSCAFP00000046375	E1A binding protein p300.	Myocyte enhancer factor 2A.	0.858
EP300	MEF2C	ENSCAFP00000001585	ENSCAFP00000053374	E1A binding protein p300.	Myocyte enhancer factor 2C.	0.839
EP300	MYF5	ENSCAFP00000001585	ENSCAFP00000008695	E1A binding protein p300.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.747
ID1	MYF5	ENSCAFP00000010470	ENSCAFP00000008695	Inhibitor of DNA binding 1, HLH protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.725
MEF2A	CREBBP	ENSCAFP00000046375	ENSCAFP00000036447	Myocyte enhancer factor 2A.	CREB binding protein.	0.554
MEF2A	EP300	ENSCAFP00000046375	ENSCAFP00000001585	Myocyte enhancer factor 2A.	E1A binding protein p300.	0.858
MEF2A	MEF2C	ENSCAFP00000046375	ENSCAFP00000053374	Myocyte enhancer factor 2A.	Myocyte enhancer factor 2C.	0.995
MEF2A	MYF5	ENSCAFP00000046375	ENSCAFP00000008695	Myocyte enhancer factor 2A.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.683
MEF2A	PAX3	ENSCAFP00000046375	ENSCAFP00000023626	Myocyte enhancer factor 2A.	Paired box 3.	0.488
MEF2A	PAX7	ENSCAFP00000046375	ENSCAFP00000022903	Myocyte enhancer factor 2A.	Paired box 7.	0.547
MEF2C	CREBBP	ENSCAFP00000053374	ENSCAFP00000036447	Myocyte enhancer factor 2C.	CREB binding protein.	0.730
MEF2C	EP300	ENSCAFP00000053374	ENSCAFP00000001585	Myocyte enhancer factor 2C.	E1A binding protein p300.	0.839
MEF2C	MEF2A	ENSCAFP00000053374	ENSCAFP00000046375	Myocyte enhancer factor 2C.	Myocyte enhancer factor 2A.	0.995
MEF2C	MSTN	ENSCAFP00000053374	ENSCAFP00000013840	Myocyte enhancer factor 2C.	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	0.462
MEF2C	MYF5	ENSCAFP00000053374	ENSCAFP00000008695	Myocyte enhancer factor 2C.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.750

page 1 of 3

Server load: low (28%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About