STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (1043 aa)    
Predicted Functional Partners:
PLEKHA8
Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...]
      
 0.742
PTPRQ
Protein tyrosine phosphatase receptor type Q.
    
 
 0.663
TMCC3
Transmembrane and coiled-coil domain family 3.
      
 0.650
HSPB3
Heat shock protein family B (small) member 3; Belongs to the small heat shock protein (HSP20) family.
      
 0.637
INTS1
Integrator complex subunit 1.
    
 
 0.637
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
    
 
 0.617
FRMD4B
FERM domain containing 4B.
      
 0.599
INTS13
Integrator complex subunit 13.
   
 
 0.578
TRIP4
Thyroid hormone receptor interactor 4.
   
  
 0.569
CLCA4
Chloride channel accessory 4.
    
 
 0.558
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.