Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IKIK cytokine. (547 aa)    
Predicted Functional Partners:
SMU1
SMU1 DNA replication regulator and spliceosomal factor.
   
 0.979
PRPF6
Pre-mRNA processing factor 6.
   
 0.943
PRPF3
Pre-mRNA processing factor 3.
   
  0.907
WDR55
WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family.
 
 
    0.902
EFTUD2
Elongation factor Tu GTP binding domain containing 2.
   
 0.893
SNIP1
Smad nuclear interacting protein 1.
   
  0.890
SF3B3
Splicing factor 3b subunit 3.
    
  0.845
MFAP1
Microfibril associated protein 1.
   
 
 0.837
XAB2
XPA binding protein 2.
   
   0.827
RBM10
RNA binding motif protein 10.
   
   0.823
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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