STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2R4V7_CANLFUncharacterized protein. (294 aa)    
Predicted Functional Partners:
NCL
Nucleolin.
   
 
 0.770
NOP58
NOP58 ribonucleoprotein.
   
  
 0.665
RPL5
Ribosomal protein L5.
   
 
 0.592
ENSCAFP00000066400
Ribosomal_L18_c domain-containing protein.
   
 
 0.592
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 
 0.587
NASP
Nuclear autoantigenic sperm protein.
   
  
 0.554
FBL
Fibrillarin.
   
 
 0.525
FBLL1
Fibrillarin like 1.
   
 
 0.525
ASF1B
Uncharacterized protein.
   
  
 0.522
CDKN2A
Cyclin dependent kinase inhibitor 2B.
    
 
 0.497
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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