STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (928 aa)    
Predicted Functional Partners:
MAP3K11
Mitogen-activated protein kinase kinase kinase 11.
    
 0.948
GRB2
Growth factor receptor bound protein 2.
   
 
 0.934
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 0.900
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
    
 0.889
CRKL
CRK like proto-oncogene, adaptor protein.
    
 
 0.875
NCK1
Cytoplasmic protein.
    
 
 0.849
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.839
LCP2
Lymphocyte cytosolic protein 2.
    
 
 0.837
GRAP2
GRB2 related adaptor protein 2.
   
 
 0.832
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.819
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.