STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMX4Thioredoxin related transmembrane protein 4. (311 aa)    
Predicted Functional Partners:
TMX2
Thioredoxin related transmembrane protein 2.
    
 
 0.751
TMEM161A
Transmembrane protein 161A.
      
 0.734
CANX
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...]
   
 
 0.701
VKORC1
Vitamin K epoxide reductase complex subunit 1.
      
 0.692
PRDX3
Thioredoxin domain-containing protein.
   
 
 0.666
HSD11B1
Hydroxysteroid 11-beta dehydrogenase 1.
    
 
 0.641
TMX3
Thioredoxin related transmembrane protein 3.
   
 
 0.620
VAMP1
Vesicle associated membrane protein 1.
    
 
 0.612
TMEM214
Transmembrane protein 214.
   
  
 0.603
SUOX
Sulfite oxidase.
    
 0.583
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.