STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NALCNSodium leak channel, non-selective. (1776 aa)    
Predicted Functional Partners:
UNC80
Unc-80 homolog, NALCN channel complex subunit.
   
 0.997
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.991
FAM155B
Family with sequence similarity 155 member B.
   
 
 0.858
FAM155A
Family with sequence similarity 155 member A.
   
 
 0.858
NAV1
Neuron navigator 1.
      
 0.729
HCN3
Hyperpolarization activated cyclic nucleotide gated potassium channel 3.
   
 
 0.679
SCN1B
Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
   
 
 0.656
AP4E1
Adaptor related protein complex 4 subunit epsilon 1.
    
 
 0.607
TPC3
Uncharacterized protein.
   
 
 0.596
ASIC4
Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.542
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.