ERCC5 protein (Canis lupus familiaris) - STRING interaction network

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Score

ERCC5

Uncharacterized protein. (1627 aa)

Predicted Functional Partners:

GTF2H1

0.980

ERCC6

0.970

ERCC2

0.968

ERCC3

0.964

EP300

0.941

BRCA2

0.936

XPA

0.901

BRCA1

0.881

GTF2H2

0.876

MUS81

0.872

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRCA2	ENSCAFP00000048759	ENSCAFP00000009557	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA2 DNA repair associated.	0.999
BRCA1	EP300	ENSCAFP00000048759	ENSCAFP00000001585	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E1A binding protein p300.	0.763
BRCA1	ERCC2	ENSCAFP00000048759	ENSCAFP00000062336	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.536
BRCA1	ERCC5	ENSCAFP00000048759	ENSCAFP00000008988	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Uncharacterized protein.	0.881
BRCA1	MUS81	ENSCAFP00000048759	ENSCAFP00000019472	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MUS81 structure-specific endonuclease subunit.	0.672
BRCA1	XPA	ENSCAFP00000048759	ENSCAFP00000003578	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	XPA, DNA damage recognition and repair factor.	0.565
BRCA2	BRCA1	ENSCAFP00000009557	ENSCAFP00000048759	BRCA2 DNA repair associated.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BRCA2	ERCC5	ENSCAFP00000009557	ENSCAFP00000008988	BRCA2 DNA repair associated.	Uncharacterized protein.	0.936
BRCA2	MUS81	ENSCAFP00000009557	ENSCAFP00000019472	BRCA2 DNA repair associated.	MUS81 structure-specific endonuclease subunit.	0.892
BRCA2	XPA	ENSCAFP00000009557	ENSCAFP00000003578	BRCA2 DNA repair associated.	XPA, DNA damage recognition and repair factor.	0.541
EP300	BRCA1	ENSCAFP00000001585	ENSCAFP00000048759	E1A binding protein p300.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.763
EP300	ERCC5	ENSCAFP00000001585	ENSCAFP00000008988	E1A binding protein p300.	Uncharacterized protein.	0.941
EP300	ERCC6	ENSCAFP00000001585	ENSCAFP00000009895	E1A binding protein p300.	ERCC excision repair 6, chromatin remodeling factor.	0.837
EP300	XPA	ENSCAFP00000001585	ENSCAFP00000003578	E1A binding protein p300.	XPA, DNA damage recognition and repair factor.	0.837
ERCC2	BRCA1	ENSCAFP00000062336	ENSCAFP00000048759	ERCC excision repair 2, TFIIH core complex helicase subunit.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.536
ERCC2	ERCC3	ENSCAFP00000062336	ENSCAFP00000006738	ERCC excision repair 2, TFIIH core complex helicase subunit.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.997
ERCC2	ERCC5	ENSCAFP00000062336	ENSCAFP00000008988	ERCC excision repair 2, TFIIH core complex helicase subunit.	Uncharacterized protein.	0.968
ERCC2	ERCC6	ENSCAFP00000062336	ENSCAFP00000009895	ERCC excision repair 2, TFIIH core complex helicase subunit.	ERCC excision repair 6, chromatin remodeling factor.	0.761
ERCC2	GTF2H1	ENSCAFP00000062336	ENSCAFP00000013505	ERCC excision repair 2, TFIIH core complex helicase subunit.	General transcription factor IIH subunit 1.	0.994
ERCC2	GTF2H2	ENSCAFP00000062336	ENSCAFP00000011552	ERCC excision repair 2, TFIIH core complex helicase subunit.	General transcription factor IIH subunit.	0.994