TRIM21 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TRIM21

Tripartite motif containing 21. (469 aa)

Predicted Functional Partners:

DDX41

0.903

RPS27A

0.587

TRIM23

0.570

UBA52

0.517

TRIM54

0.513

TRIM47

0.482

SHISA5

0.466

SQSTM1

0.456

GANC

0.436

WWP1

0.436

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX41	RPS27A	ENSCAFP00000038676	ENSCAFP00000031429	DEAD-box helicase 41.	Ubiquitin-like domain-containing protein.	0.400
DDX41	TRIM21	ENSCAFP00000038676	ENSCAFP00000009023	DEAD-box helicase 41.	Tripartite motif containing 21.	0.903
DDX41	UBA52	ENSCAFP00000038676	ENSCAFP00000021714	DEAD-box helicase 41.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.400
GANC	TRIM21	ENSCAFP00000014854	ENSCAFP00000009023	Glucosidase alpha, neutral C; Belongs to the glycosyl hydrolase 31 family.	Tripartite motif containing 21.	0.436
RPS27A	DDX41	ENSCAFP00000031429	ENSCAFP00000038676	Ubiquitin-like domain-containing protein.	DEAD-box helicase 41.	0.400
RPS27A	SQSTM1	ENSCAFP00000031429	ENSCAFP00000065910	Ubiquitin-like domain-containing protein.	Sequestosome 1.	0.975
RPS27A	TRIM21	ENSCAFP00000031429	ENSCAFP00000009023	Ubiquitin-like domain-containing protein.	Tripartite motif containing 21.	0.587
RPS27A	UBA52	ENSCAFP00000031429	ENSCAFP00000021714	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.993
RPS27A	WWP1	ENSCAFP00000031429	ENSCAFP00000047368	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase.	0.766
SHISA5	TRIM21	ENSCAFP00000060742	ENSCAFP00000009023	Shisa family member 5.	Tripartite motif containing 21.	0.466
SQSTM1	RPS27A	ENSCAFP00000065910	ENSCAFP00000031429	Sequestosome 1.	Ubiquitin-like domain-containing protein.	0.975
SQSTM1	TRIM21	ENSCAFP00000065910	ENSCAFP00000009023	Sequestosome 1.	Tripartite motif containing 21.	0.456
SQSTM1	TRIM47	ENSCAFP00000065910	ENSCAFP00000007367	Sequestosome 1.	Tripartite motif containing 47.	0.460
SQSTM1	TRIM54	ENSCAFP00000065910	ENSCAFP00000065241	Sequestosome 1.	Tripartite motif containing 54.	0.507
SQSTM1	UBA52	ENSCAFP00000065910	ENSCAFP00000021714	Sequestosome 1.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.872
TRIM21	DDX41	ENSCAFP00000009023	ENSCAFP00000038676	Tripartite motif containing 21.	DEAD-box helicase 41.	0.903
TRIM21	GANC	ENSCAFP00000009023	ENSCAFP00000014854	Tripartite motif containing 21.	Glucosidase alpha, neutral C; Belongs to the glycosyl hydrolase 31 family.	0.436
TRIM21	RPS27A	ENSCAFP00000009023	ENSCAFP00000031429	Tripartite motif containing 21.	Ubiquitin-like domain-containing protein.	0.587
TRIM21	SHISA5	ENSCAFP00000009023	ENSCAFP00000060742	Tripartite motif containing 21.	Shisa family member 5.	0.466
TRIM21	SQSTM1	ENSCAFP00000009023	ENSCAFP00000065910	Tripartite motif containing 21.	Sequestosome 1.	0.456