CNTN4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CNTN4

Contactin 4. (1026 aa)

Predicted Functional Partners:

PTPRG

0.848

APP

0.790

CNTNAP5

0.685

APLP2

0.660

MYOM2-2

0.649

CDH4

0.624

PTPRZ1

0.589

TSNARE1

0.583

APLP1

0.579

PTPRA

0.553

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP1	APLP2	ENSCAFP00000066098	ENSCAFP00000014894	Amyloid beta precursor like protein 1.	Amyloid beta precursor like protein 2.	0.411
APLP1	APP	ENSCAFP00000066098	ENSCAFP00000012583	Amyloid beta precursor like protein 1.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.418
APLP1	CNTN4	ENSCAFP00000066098	ENSCAFP00000009030	Amyloid beta precursor like protein 1.	Contactin 4.	0.579
APLP2	APLP1	ENSCAFP00000014894	ENSCAFP00000066098	Amyloid beta precursor like protein 2.	Amyloid beta precursor like protein 1.	0.411
APLP2	APP	ENSCAFP00000014894	ENSCAFP00000012583	Amyloid beta precursor like protein 2.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.572
APLP2	CNTN4	ENSCAFP00000014894	ENSCAFP00000009030	Amyloid beta precursor like protein 2.	Contactin 4.	0.660
APLP2	PTPRA	ENSCAFP00000014894	ENSCAFP00000055067	Amyloid beta precursor like protein 2.	Receptor-type tyrosine-protein phosphatase alpha.	0.424
APP	APLP1	ENSCAFP00000012583	ENSCAFP00000066098	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor like protein 1.	0.418
APP	APLP2	ENSCAFP00000012583	ENSCAFP00000014894	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor like protein 2.	0.572
APP	CNTN4	ENSCAFP00000012583	ENSCAFP00000009030	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Contactin 4.	0.790
CDH4	CNTN4	ENSCAFP00000053845	ENSCAFP00000009030	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins.	Contactin 4.	0.624
CDH4	MYOM2-2	ENSCAFP00000053845	ENSCAFP00000021211	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins.	Ig-like domain-containing protein.	0.651
CNTN4	APLP1	ENSCAFP00000009030	ENSCAFP00000066098	Contactin 4.	Amyloid beta precursor like protein 1.	0.579
CNTN4	APLP2	ENSCAFP00000009030	ENSCAFP00000014894	Contactin 4.	Amyloid beta precursor like protein 2.	0.660
CNTN4	APP	ENSCAFP00000009030	ENSCAFP00000012583	Contactin 4.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.790
CNTN4	CDH4	ENSCAFP00000009030	ENSCAFP00000053845	Contactin 4.	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins.	0.624
CNTN4	CNTNAP5	ENSCAFP00000009030	ENSCAFP00000006992	Contactin 4.	Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family.	0.685
CNTN4	MYOM2-2	ENSCAFP00000009030	ENSCAFP00000021211	Contactin 4.	Ig-like domain-containing protein.	0.649
CNTN4	PTPRA	ENSCAFP00000009030	ENSCAFP00000055067	Contactin 4.	Receptor-type tyrosine-protein phosphatase alpha.	0.553
CNTN4	PTPRG	ENSCAFP00000009030	ENSCAFP00000056443	Contactin 4.	Protein tyrosine phosphatase receptor type G.	0.848