Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FASNFatty acid synthase. (2478 aa)    
Predicted Functional Partners:
ACLY
ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
   
 0.995
ACACA
Acetyl-CoA carboxylase alpha.
  
 
 0.982
ACSL1
Acyl-CoA synthetase long chain family member 1.
    
 0.951
MCAT
Malonyl-CoA-acyl carrier protein transacylase.
  
 
 0.950
ACSF3
Acyl-CoA synthetase family member 3.
  
 0.945
ACSL3
Acyl-CoA synthetase long chain family member 3.
  
 
 0.944
ACACB
Acetyl-CoA carboxylase beta.
  
 
 0.942
ACSL5
Acyl-CoA synthetase long chain family member 5.
    
 0.940
CS
Citrate synthase; Belongs to the citrate synthase family.
   
 
 0.939
ACSL4
Acyl-CoA synthetase long chain family member 4.
  
 
 0.930
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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