STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa)    
Predicted Functional Partners:
DNAJC3
DnaJ heat shock protein family (Hsp40) member C3.
   
 0.997
EIF2S1
Eukaryotic translation initiation factor 2 subunit alpha.
   
 0.996
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
  
0.995
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
  
0.990
TARBP2
RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]
    
 0.985
ILF3
Interleukin enhancer binding factor 3.
    
 0.985
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.978
STAT1
Signal transducer and activator of transcription.
   
 0.976
ADAR
Adenosine deaminase RNA specific.
   
0.966
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.966
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.