IRS2 protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

IRS2

Insulin receptor substrate 2. (1382 aa)

Predicted Functional Partners:

PTPN11

0.992

GRB2

0.986

IGF1R

0.983

INSR

0.981

PIK3R1

0.978

INS

0.976

PIK3R3

0.973

PIK3R2

0.959

PIK3CA

0.954

IKBKB

0.950

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IGF1R	ENSCAFP00000049390	ENSCAFP00000043796	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.949
GRB2	INS	ENSCAFP00000049390	ENSCAFP00000051648	Growth factor receptor bound protein 2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.713
GRB2	INSR	ENSCAFP00000049390	ENSCAFP00000038176	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.948
GRB2	IRS2	ENSCAFP00000049390	ENSCAFP00000009098	Growth factor receptor bound protein 2.	Insulin receptor substrate 2.	0.986
GRB2	PIK3CA	ENSCAFP00000049390	ENSCAFP00000048355	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.689
GRB2	PIK3R1	ENSCAFP00000049390	ENSCAFP00000011322	Growth factor receptor bound protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.948
GRB2	PIK3R2	ENSCAFP00000049390	ENSCAFP00000022072	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.745
GRB2	PIK3R3	ENSCAFP00000049390	ENSCAFP00000006438	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.764
GRB2	PTPN11	ENSCAFP00000049390	ENSCAFP00000013074	Growth factor receptor bound protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.995
IGF1R	GRB2	ENSCAFP00000043796	ENSCAFP00000049390	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 2.	0.949
IGF1R	INS	ENSCAFP00000043796	ENSCAFP00000051648	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.992
IGF1R	INSR	ENSCAFP00000043796	ENSCAFP00000038176	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.987
IGF1R	IRS2	ENSCAFP00000043796	ENSCAFP00000009098	Tyrosine-protein kinase receptor.	Insulin receptor substrate 2.	0.983
IGF1R	PIK3CA	ENSCAFP00000043796	ENSCAFP00000048355	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.958
IGF1R	PIK3R1	ENSCAFP00000043796	ENSCAFP00000011322	Tyrosine-protein kinase receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.970
IGF1R	PIK3R2	ENSCAFP00000043796	ENSCAFP00000022072	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.945
IGF1R	PIK3R3	ENSCAFP00000043796	ENSCAFP00000006438	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.947
IGF1R	PTPN11	ENSCAFP00000043796	ENSCAFP00000013074	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.664
IKBKB	INS	ENSCAFP00000048001	ENSCAFP00000051648	Inhibitor of nuclear factor kappa B kinase subunit beta.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.502
IKBKB	IRS2	ENSCAFP00000048001	ENSCAFP00000009098	Inhibitor of nuclear factor kappa B kinase subunit beta.	Insulin receptor substrate 2.	0.950