STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
COL4A1Collagen type IV alpha 1 chain. (1586 aa)    
Predicted Functional Partners:
COL4A2
Collagen type IV alpha 2 chain.
  
0.868
COL4A6
Collagen type IV alpha 6 chain.
  
0.808
PELO
Integrin subunit alpha 1; Belongs to the integrin alpha chain family.
   
 0.766
LAMC1
Laminin subunit gamma 1.
   
 0.750
FN1
Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).
   
 0.737
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.734
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
    
 0.729
ITGA11
Integrin subunit alpha 11; Belongs to the integrin alpha chain family.
   
 0.727
ITGA5
Integrin subunit alpha 5; Belongs to the integrin alpha chain family.
   
 0.718
LAMA2
Laminin subunit alpha 2.
   
 0.711
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.