STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHFRCheckpoint with forkhead and ring finger domains. (726 aa)    
Predicted Functional Partners:
TBRG1
Transforming growth factor beta regulator 1.
      
 0.749
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.732
PARP3
Poly [ADP-ribose] polymerase.
   
 
 0.718
CLSPN
Claspin.
   
  
 0.707
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.679
COPS2
COP9 signalosome subunit 2.
   
  
 0.641
SLC29A2
Solute carrier family 29 member 2.
   
  
 0.634
APLF
Aprataxin and PNKP like factor.
      
 0.627
KNTC1
Kinetochore associated 1.
      
 0.596
MDC1
Mediator of DNA damage checkpoint 1.
   
  
 0.574
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.