PLPP5 protein (Canis lupus familiaris) - STRING interaction network

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PLPP5

Phospholipid phosphatase 5. (262 aa)

Predicted Functional Partners:

CDIPT

0.654

ATP6V0D1

0.610

ATP6V0D2

0.609

PLPP7

0.515

COQ2

0.494

DENND2D

0.481

ATP6V1F

0.439

MED19

0.419

PLA2G15

0.418

GPD2

0.409

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6V0D1	ATP6V0D2	ENSCAFP00000030192	ENSCAFP00000012882	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.901
ATP6V0D1	ATP6V1F	ENSCAFP00000030192	ENSCAFP00000002364	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6V0D1	PLPP5	ENSCAFP00000030192	ENSCAFP00000009150	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	Phospholipid phosphatase 5.	0.610
ATP6V0D2	ATP6V0D1	ENSCAFP00000012882	ENSCAFP00000030192	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.901
ATP6V0D2	ATP6V1F	ENSCAFP00000012882	ENSCAFP00000002364	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.992
ATP6V0D2	PLPP5	ENSCAFP00000012882	ENSCAFP00000009150	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	Phospholipid phosphatase 5.	0.609
ATP6V1F	ATP6V0D1	ENSCAFP00000002364	ENSCAFP00000030192	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.999
ATP6V1F	ATP6V0D2	ENSCAFP00000002364	ENSCAFP00000012882	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.992
ATP6V1F	PLPP5	ENSCAFP00000002364	ENSCAFP00000009150	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Phospholipid phosphatase 5.	0.439
CDIPT	PLPP5	ENSCAFP00000044470	ENSCAFP00000009150	CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Phospholipid phosphatase 5.	0.654
COQ2	PLPP5	ENSCAFP00000043242	ENSCAFP00000009150	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Phospholipid phosphatase 5.	0.494
DENND2D	PLPP5	ENSCAFP00000053699	ENSCAFP00000009150	DENN domain containing 2D.	Phospholipid phosphatase 5.	0.481
GPD2	PLPP5	ENSCAFP00000013582	ENSCAFP00000009150	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	Phospholipid phosphatase 5.	0.409
MED19	PLPP5	ENSCAFP00000011527	ENSCAFP00000009150	Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Phospholipid phosphatase 5.	0.419
PLA2G15	PLPP5	ENSCAFP00000030134	ENSCAFP00000009150	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity).	Phospholipid phosphatase 5.	0.418
PLPP5	ATP6V0D1	ENSCAFP00000009150	ENSCAFP00000030192	Phospholipid phosphatase 5.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.610
PLPP5	ATP6V0D2	ENSCAFP00000009150	ENSCAFP00000012882	Phospholipid phosphatase 5.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.609
PLPP5	ATP6V1F	ENSCAFP00000009150	ENSCAFP00000002364	Phospholipid phosphatase 5.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.439
PLPP5	CDIPT	ENSCAFP00000009150	ENSCAFP00000044470	Phospholipid phosphatase 5.	CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.654
PLPP5	COQ2	ENSCAFP00000009150	ENSCAFP00000043242	Phospholipid phosphatase 5.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.494