STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ANKLE2Ankyrin repeat and LEM domain containing 2. (959 aa)    
Predicted Functional Partners:
VRK1
VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily.
   
 0.935
VRK2
VRK serine/threonine kinase 2.
   
 0.932
ANKLE1
Ankyrin repeat and LEM domain containing 1.
    
 0.897
PPP2CA
Serine/threonine-protein phosphatase.
    
 0.848
PPP2R1A
Protein phosphatase 2 scaffold subunit Aalpha.
    
  0.847
HAUS5
HAUS augmin like complex subunit 5.
      
 0.810
NEK11
NIMA related kinase 11.
    
 
 0.799
SPECC1
Sperm antigen with calponin homology and coiled-coil domains 1.
   
 
 0.751
DCHS2
Dachsous cadherin-related 2.
     
 0.750
BCAM
Basal cell adhesion molecule.
    
 
 0.737
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.