STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIAPH1Diaphanous related formin 1. (1283 aa)    
Predicted Functional Partners:
DIAPH2
Diaphanous related formin 2.
  
  
0.927
PFN4
Profilin; Belongs to the profilin family.
    
 0.924
AGER
Advanced glycosylation end product-specific receptor variant C.
    
 0.913
PFN2
Profilin; Belongs to the profilin family.
    
 0.907
LOC106558389
Profilin; Belongs to the profilin family.
    
 0.907
RHOC
Uncharacterized protein.
   
 0.864
PFN1
Profilin; Belongs to the profilin family.
    
 0.831
RHOA
Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]
   
 0.768
DAAM1
Dishevelled associated activator of morphogenesis 1.
    
0.768
CDC42
Cell division cycle 42.
   
 0.757
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (16%) [HD]