STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)    
Predicted Functional Partners:
SPG11
SPG11 vesicle trafficking associated, spatacsin.
    
 
 0.916
AP5M1
Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family.
    
 
 0.902
AP5B1
Adaptor related protein complex 5 subunit beta 1.
     
  0.900
AP5Z1
Adaptor related protein complex 5 subunit zeta 1.
    
 0.854
AP4M1
AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and [...]
    
 0.739
ZFYVE26
Zinc finger FYVE-type containing 26.
    
 
 0.703
ZNF367
Zinc finger protein 367.
      
 0.692
ARFGAP2
ADP ribosylation factor GTPase activating protein 2.
      
 0.692
ZBTB3
Zinc finger and BTB domain containing 3.
      
 0.692
ARL1
ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family.
      
 0.681
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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