STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC609402Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (258 aa)    
Predicted Functional Partners:
LOC100855540
Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.
  
0.989
LOC479668
Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...]
   
 
 0.986
LOC100855600
GLOBIN domain-containing protein; Belongs to the globin family.
   
0.904
ENSCAFP00000055974
GLOBIN domain-containing protein; Belongs to the globin family.
  
 
 0.840
HBM
Hemoglobin subunit mu; Belongs to the globin family.
   
 
0.801
MASP1
Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family.
   
 
 0.708
BCL11A
BAF chromatin remodeling complex subunit BCL11A.
      
 0.694
AHSP
Alpha hemoglobin stabilizing protein.
   
 
 0.657
EPAS1
Endothelial PAS domain protein 1.
   
  
 0.600
EDNRB
Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
   
  
 0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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