UBE2N protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

UBE2N

UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)

Predicted Functional Partners:

UBE2V2

0.874

TRAF6

0.774

TRIP12

0.731

ENSCAFP00000047437

0.726

ATXN1L

0.704

UBA7

0.696

U2SURP

0.691

RNF8

0.634

FANCM

0.630

TGM7

0.622

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1L	U2SURP	ENSCAFP00000032624	ENSCAFP00000011818	Ataxin 1 like.	U2 snRNP associated SURP domain containing.	0.867
ATXN1L	UBA7	ENSCAFP00000032624	ENSCAFP00000016471	Ataxin 1 like.	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.690
ATXN1L	UBE2N	ENSCAFP00000032624	ENSCAFP00000009272	Ataxin 1 like.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.704
ENSCAFP00000047437	FANCM	ENSCAFP00000047437	ENSCAFP00000041513	Uncharacterized protein.	FA complementation group M.	0.659
ENSCAFP00000047437	RNF8	ENSCAFP00000047437	ENSCAFP00000053376	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.596
ENSCAFP00000047437	TRAF6	ENSCAFP00000047437	ENSCAFP00000010159	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.729
ENSCAFP00000047437	UBE2N	ENSCAFP00000047437	ENSCAFP00000009272	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.726
ENSCAFP00000047437	UBE2V2	ENSCAFP00000047437	ENSCAFP00000038211	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 V2.	0.433
FANCM	ENSCAFP00000047437	ENSCAFP00000041513	ENSCAFP00000047437	FA complementation group M.	Uncharacterized protein.	0.659
FANCM	UBE2N	ENSCAFP00000041513	ENSCAFP00000009272	FA complementation group M.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.630
FANCM	UBE2V2	ENSCAFP00000041513	ENSCAFP00000038211	FA complementation group M.	Ubiquitin conjugating enzyme E2 V2.	0.659
RNF8	ENSCAFP00000047437	ENSCAFP00000053376	ENSCAFP00000047437	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Uncharacterized protein.	0.596
RNF8	TRIP12	ENSCAFP00000053376	ENSCAFP00000057207	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Thyroid hormone receptor interactor 12.	0.500
RNF8	UBE2N	ENSCAFP00000053376	ENSCAFP00000009272	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.634
RNF8	UBE2V2	ENSCAFP00000053376	ENSCAFP00000038211	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Ubiquitin conjugating enzyme E2 V2.	0.625
TGM7	UBE2N	ENSCAFP00000017721	ENSCAFP00000009272	Transglutaminase 7.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.622
TRAF6	ENSCAFP00000047437	ENSCAFP00000010159	ENSCAFP00000047437	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Uncharacterized protein.	0.729
TRAF6	UBE2N	ENSCAFP00000010159	ENSCAFP00000009272	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.774
TRAF6	UBE2V2	ENSCAFP00000010159	ENSCAFP00000038211	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Ubiquitin conjugating enzyme E2 V2.	0.724
TRIP12	RNF8	ENSCAFP00000057207	ENSCAFP00000053376	Thyroid hormone receptor interactor 12.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.500

page 1 of 3

Server load: low (22%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About