STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SOCS2Suppressor of cytokine signaling 2. (299 aa)    
Predicted Functional Partners:
ELOB
Elongin B.
    
 0.904
GHR
Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).
    
 
 0.903
ELOC
Elongin C; Belongs to the SKP1 family.
    
 0.875
STAT3
Signal transducer and activator of transcription.
   
 0.874
JAK2
Janus kinase 2.
    
 0.873
STAT1
Signal transducer and activator of transcription.
   
 0.867
CUL5
Cullin 5; Belongs to the cullin family.
   
 
 0.864
SOCS5
Suppressor of cytokine signaling 5.
     
0.852
SOCS1
Suppressor of cytokine signaling 1.
    
 0.851
STAT5B
Signal transducer and activator of transcription.
   
 0.844
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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