STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLXNC1Plexin C1. (1594 aa)    
Predicted Functional Partners:
SEMA7A
Semaphorin 7A; Belongs to the semaphorin family.
    
 0.997
SEMA4D
Semaphorin 4D; Belongs to the semaphorin family.
    
 
 0.776
SEMA5A
Semaphorin 5A.
    
 
 0.675
SEMA3F
Semaphorin 3F; Belongs to the semaphorin family.
    
 
 0.638
SEMA6B
Semaphorin 6B; Belongs to the semaphorin family.
    
 
 0.633
GPR157
G protein-coupled receptor 157.
      
 0.619
SEMA6D
Semaphorin 6D; Belongs to the semaphorin family.
    
 
 0.618
SEMA3E
Semaphorin 3E; Belongs to the semaphorin family.
    
 
 0.605
NRP1
Neuropilin 1.
   
 
 0.578
CACNG7
Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
    
 
 0.566
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.