F1PX18_CANLF protein (Canis lupus familiaris)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

F1PX18_CANLF

Olfactory receptor. (318 aa)

Predicted Functional Partners:

GNG10

0.516

HMGCLL1

0.487

DEFB124

0.482

GALNT13

0.455

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEFB124	F1PX18_CANLF	ENSCAFP00000034176	ENSCAFP00000009314	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Olfactory receptor.	0.482
DEFB124	GALNT13	ENSCAFP00000034176	ENSCAFP00000013487	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Polypeptide N-acetylgalactosaminyltransferase.	0.677
DEFB124	GNG10	ENSCAFP00000034176	ENSCAFP00000028529	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.681
DEFB124	HMGCLL1	ENSCAFP00000034176	ENSCAFP00000055926	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.746
F1PX18_CANLF	DEFB124	ENSCAFP00000009314	ENSCAFP00000034176	Olfactory receptor.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.482
F1PX18_CANLF	GALNT13	ENSCAFP00000009314	ENSCAFP00000013487	Olfactory receptor.	Polypeptide N-acetylgalactosaminyltransferase.	0.455
F1PX18_CANLF	GNG10	ENSCAFP00000009314	ENSCAFP00000028529	Olfactory receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.516
F1PX18_CANLF	HMGCLL1	ENSCAFP00000009314	ENSCAFP00000055926	Olfactory receptor.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.487
GALNT13	DEFB124	ENSCAFP00000013487	ENSCAFP00000034176	Polypeptide N-acetylgalactosaminyltransferase.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.677
GALNT13	F1PX18_CANLF	ENSCAFP00000013487	ENSCAFP00000009314	Polypeptide N-acetylgalactosaminyltransferase.	Olfactory receptor.	0.455
GALNT13	GNG10	ENSCAFP00000013487	ENSCAFP00000028529	Polypeptide N-acetylgalactosaminyltransferase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.558
GALNT13	HMGCLL1	ENSCAFP00000013487	ENSCAFP00000055926	Polypeptide N-acetylgalactosaminyltransferase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.687
GNG10	DEFB124	ENSCAFP00000028529	ENSCAFP00000034176	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.681
GNG10	F1PX18_CANLF	ENSCAFP00000028529	ENSCAFP00000009314	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Olfactory receptor.	0.516
GNG10	GALNT13	ENSCAFP00000028529	ENSCAFP00000013487	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Polypeptide N-acetylgalactosaminyltransferase.	0.558
GNG10	HMGCLL1	ENSCAFP00000028529	ENSCAFP00000055926	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.679
HMGCLL1	DEFB124	ENSCAFP00000055926	ENSCAFP00000034176	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.746
HMGCLL1	F1PX18_CANLF	ENSCAFP00000055926	ENSCAFP00000009314	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Olfactory receptor.	0.487
HMGCLL1	GALNT13	ENSCAFP00000055926	ENSCAFP00000013487	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Polypeptide N-acetylgalactosaminyltransferase.	0.687
HMGCLL1	GNG10	ENSCAFP00000055926	ENSCAFP00000028529	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.679

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

9 of 1311

1.1

1.21

1.12e-05

GO:0007165

Signal transduction

11 of 4180

0.68

0.59

0.00016

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

5 of 39

2.37

3.69

5.31e-08

GO:0031681

G-protein beta-subunit binding

3 of 24

2.36

1.95

0.00021

GO:0003924

GTPase activity

6 of 338

1.51

1.86

1.00e-05

GO:0051020

GTPase binding

4 of 279

1.42

1.07

0.0031

GO:0019899

Enzyme binding

6 of 1712

0.81

0.48

0.0297

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

7 of 36

2.55

6.58

5.97e-14

GO:0005886

Plasma membrane

10 of 4723

0.59

0.49

0.00055

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32466321

(2020) Oviductal Extracellular Vesicles Improve Post-Thaw Sperm Function in Red Wolves and Cheetahs.

3 of 27

2.31

0.92

0.0201

PMID:19375447

(2009) Naturally occurring animal models with outer retina phenotypes.

3 of 24

2.36

0.92

0.0201

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18961

G beta:gamma signalling through BTK, and Phosducin

6 of 11

3.0

6.74

2.72e-13

CL:18951

G alpha (i) signalling events, and Inward rectifier potassium channel activity

8 of 131

2.05

4.9

1.49e-12

CL:18953

Mixed, incl. GABA B receptor activation, and Regulator of G protein signalling domain

7 of 98

2.12

4.66

2.87e-11

CL:18963

G beta:gamma signalling through BTK, and Serotonin receptors

4 of 6

3.09

4.53

4.99e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04062

Chemokine signaling pathway

11 of 159

2.1

7.47

3.57e-21

cfa04727

GABAergic synapse

8 of 73

2.3

6.83

5.06e-16

cfa05032

Morphine addiction

8 of 77

2.28

6.75

5.41e-16

cfa04713

Circadian entrainment

8 of 85

2.24

6.52

1.00e-15

cfa04726

Serotonergic synapse

8 of 91

2.21

6.36

1.49e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-8964315

G beta:gamma signalling through BTK

8 of 17

2.94

9.59

4.14e-19

CFA-8964616

G beta:gamma signalling through CDC42

8 of 19

2.89

9.51

4.24e-19

CFA-418217

G beta:gamma signalling through PLC beta

8 of 19

2.89

9.51

4.24e-19

CFA-500657

Presynaptic function of Kainate receptors

8 of 20

2.87

9.48

4.24e-19

CFA-400042

Adrenaline,noradrenaline inhibits insulin secretion

8 of 20

2.87

9.48

4.24e-19

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP1165

G protein signaling pathways

5 of 75

2.09

3.65

1.20e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

6 of 25

2.64

5.76

6.55e-12

GOCC:0031680

G-protein beta/gamma-subunit complex

2 of 5

2.87

1.65

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 244

1.58

1.75

4.89e-05

KW-0449

Lipoprotein

3 of 127

1.64

1.0

0.0085

KW-0807

Transducer

5 of 1006

0.96

0.61

0.0153

KW-0677

Repeat

5 of 1186

0.89

0.53

0.0249

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020472

G-protein beta WD-40 repeat

2 of 2

3.26

1.64

0.0011

IPR019775

WD40 repeat, conserved site

2 of 3

3.09

1.64

0.0011

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR036322

WD40-repeat-containing domain superfamily

2 of 4

2.96

1.63

0.0011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

3 of 17

2.51

2.12

0.00011

SM00320

WD40 repeats

5 of 269

1.53

1.6

0.00011

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