close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)    
Predicted Functional Partners:
PLXNA3
Plexin A3.
    
 0.999
NRP1
Neuropilin 1.
   
 0.999
CHCHD6
MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
    
 0.990
PLXNA4
Plexin A4.
    
0.977
PLXNA2
Plexin A2.
    
 0.975
NRP2
Neuropilin; Belongs to the neuropilin family.
    
 
 0.811
CRMP1
Collapsin response mediator protein 1.
     
 0.804
FARP2
FERM, ARH/RhoGEF and pleckstrin domain protein 2.
     
 0.732
NTN1
Netrin 1.
      
 0.731
EFNB2
Ephrin B2; Belongs to the ephrin family.
      
 0.707
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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