TTI2 protein (Canis lupus familiaris) - STRING interaction network

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Score

TTI2

TELO2 interacting protein 2. (508 aa)

Predicted Functional Partners:

TTI1

0.989

TELO2

0.850

RUVBL2

0.698

SUOX

0.690

TRRAP

0.622

BTBD8

0.572

MAK16

0.560

ATM

0.520

PIH1D1

0.520

AKAP10

0.518

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP10	TTI2	ENSCAFP00000026745	ENSCAFP00000009475	A-kinase anchoring protein 10.	TELO2 interacting protein 2.	0.518
ATM	TELO2	ENSCAFP00000035996	ENSCAFP00000038995	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere maintenance 2.	0.893
ATM	TRRAP	ENSCAFP00000035996	ENSCAFP00000045167	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.546
ATM	TTI1	ENSCAFP00000035996	ENSCAFP00000045584	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TELO2 interacting protein 1.	0.795
ATM	TTI2	ENSCAFP00000035996	ENSCAFP00000009475	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TELO2 interacting protein 2.	0.520
BTBD8	TTI2	ENSCAFP00000055317	ENSCAFP00000009475	BTB domain containing 8.	TELO2 interacting protein 2.	0.572
MAK16	TTI2	ENSCAFP00000039914	ENSCAFP00000009475	MAK16 homolog.	TELO2 interacting protein 2.	0.560
PIH1D1	RUVBL2	ENSCAFP00000066013	ENSCAFP00000005741	PIH1 domain containing 1.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.998
PIH1D1	TELO2	ENSCAFP00000066013	ENSCAFP00000038995	PIH1 domain containing 1.	Telomere maintenance 2.	0.824
PIH1D1	TTI1	ENSCAFP00000066013	ENSCAFP00000045584	PIH1 domain containing 1.	TELO2 interacting protein 1.	0.745
PIH1D1	TTI2	ENSCAFP00000066013	ENSCAFP00000009475	PIH1 domain containing 1.	TELO2 interacting protein 2.	0.520
RUVBL2	PIH1D1	ENSCAFP00000005741	ENSCAFP00000066013	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	PIH1 domain containing 1.	0.998
RUVBL2	TELO2	ENSCAFP00000005741	ENSCAFP00000038995	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	Telomere maintenance 2.	0.821
RUVBL2	TRRAP	ENSCAFP00000005741	ENSCAFP00000045167	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.991
RUVBL2	TTI1	ENSCAFP00000005741	ENSCAFP00000045584	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	TELO2 interacting protein 1.	0.897
RUVBL2	TTI2	ENSCAFP00000005741	ENSCAFP00000009475	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	TELO2 interacting protein 2.	0.698
SUOX	TTI2	ENSCAFP00000065414	ENSCAFP00000009475	Sulfite oxidase.	TELO2 interacting protein 2.	0.690
TELO2	ATM	ENSCAFP00000038995	ENSCAFP00000035996	Telomere maintenance 2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.893
TELO2	PIH1D1	ENSCAFP00000038995	ENSCAFP00000066013	Telomere maintenance 2.	PIH1 domain containing 1.	0.824
TELO2	RUVBL2	ENSCAFP00000038995	ENSCAFP00000005741	Telomere maintenance 2.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.821