STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.999
EGFR
Receptor protein-tyrosine kinase.
    
 0.997
PTPN11
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
   
 0.996
SHC1
SHC adaptor protein 1.
   
 0.992
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.988
SHC3
SHC adaptor protein 3.
   
 0.987
KRAS
KRAS proto-oncogene, GTPase.
   
 0.986
LOC100683481
Tyrosine-protein phosphatase domain-containing protein.
    
 0.983
NRAS
Uncharacterized protein.
   
 0.980
HRAS
Uncharacterized protein.
   
 0.980
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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