STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
C21H11orf42Chromosome 21 C11orf42 homolog. (370 aa)    
Predicted Functional Partners:
ZNHIT2
Zinc finger HIT-type containing 2.
      
 0.474
LRRC36
Leucine rich repeat containing 36.
  
     0.467
SNX5
Sorting nexin 5.
    
 
 0.433
DKKL1
Dickkopf like acrosomal protein 1.
  
     0.432
PKNOX2
PBX/knotted 1 homeobox 2.
   
  
 0.417
IL22RA1
Interleukin 22 receptor subunit alpha 1.
  
     0.411
KLHDC7A
Kelch domain containing 7A.
      
 0.408
POLDIP3
DNA polymerase delta interacting protein 3.
      
 0.407
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
  
     0.406
ZNF385A
Zinc finger protein 385A.
      
 0.405
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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