TMCO3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMCO3

Transmembrane and coiled-coil domains 3. (677 aa)

Predicted Functional Partners:

TFDP1

0.758

MAN2A2

0.618

CPA1

0.618

PCID2

0.606

ASAP3

0.602

PLEKHA4

0.602

GRK7

0.600

ATP4B

0.584

GRTP1

0.579

TFDP2

0.546

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASAP3	PLEKHA4	ENSCAFP00000043123	ENSCAFP00000044065	Uncharacterized protein.	Pleckstrin homology domain containing A4.	0.553
ASAP3	TMCO3	ENSCAFP00000043123	ENSCAFP00000009546	Uncharacterized protein.	Transmembrane and coiled-coil domains 3.	0.602
ATP4B	GRTP1	ENSCAFP00000009569	ENSCAFP00000009502	Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family.	Growth hormone regulated TBC protein 1.	0.524
ATP4B	PCID2	ENSCAFP00000009569	ENSCAFP00000058221	Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family.	PCI domain containing 2.	0.472
ATP4B	TMCO3	ENSCAFP00000009569	ENSCAFP00000009546	Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family.	Transmembrane and coiled-coil domains 3.	0.584
CPA1	TMCO3	ENSCAFP00000065526	ENSCAFP00000009546	Carboxypeptidase A1.	Transmembrane and coiled-coil domains 3.	0.618
GRK7	TMCO3	ENSCAFP00000011435	ENSCAFP00000009546	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Transmembrane and coiled-coil domains 3.	0.600
GRTP1	ATP4B	ENSCAFP00000009502	ENSCAFP00000009569	Growth hormone regulated TBC protein 1.	Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family.	0.524
GRTP1	PCID2	ENSCAFP00000009502	ENSCAFP00000058221	Growth hormone regulated TBC protein 1.	PCI domain containing 2.	0.654
GRTP1	TFDP1	ENSCAFP00000009502	ENSCAFP00000063174	Growth hormone regulated TBC protein 1.	Transcription factor.	0.468
GRTP1	TMCO3	ENSCAFP00000009502	ENSCAFP00000009546	Growth hormone regulated TBC protein 1.	Transmembrane and coiled-coil domains 3.	0.579
MAN2A2	TMCO3	ENSCAFP00000018084	ENSCAFP00000009546	Alpha-mannosidase.	Transmembrane and coiled-coil domains 3.	0.618
PCID2	ATP4B	ENSCAFP00000058221	ENSCAFP00000009569	PCI domain containing 2.	Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family.	0.472
PCID2	GRTP1	ENSCAFP00000058221	ENSCAFP00000009502	PCI domain containing 2.	Growth hormone regulated TBC protein 1.	0.654
PCID2	TFDP1	ENSCAFP00000058221	ENSCAFP00000063174	PCI domain containing 2.	Transcription factor.	0.494
PCID2	TMCO3	ENSCAFP00000058221	ENSCAFP00000009546	PCI domain containing 2.	Transmembrane and coiled-coil domains 3.	0.606
PLEKHA4	ASAP3	ENSCAFP00000044065	ENSCAFP00000043123	Pleckstrin homology domain containing A4.	Uncharacterized protein.	0.553
PLEKHA4	TMCO3	ENSCAFP00000044065	ENSCAFP00000009546	Pleckstrin homology domain containing A4.	Transmembrane and coiled-coil domains 3.	0.602
TFDP1	GRTP1	ENSCAFP00000063174	ENSCAFP00000009502	Transcription factor.	Growth hormone regulated TBC protein 1.	0.468
TFDP1	PCID2	ENSCAFP00000063174	ENSCAFP00000058221	Transcription factor.	PCI domain containing 2.	0.494