ACKR4 protein (Canis lupus familiaris) - STRING interaction network

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Score

ACKR4

Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)

Predicted Functional Partners:

CCL25

0.991

CCL19

0.984

CCL8

0.933

CCL1

0.906

CCR9

0.881

CCR7

0.881

CCL13

0.868

ACKR1

0.859

CXCR6

0.695

CCL2

0.679

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	ACKR4	ENSCAFP00000035226	ENSCAFP00000009573	Atypical chemokine receptor 1.	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.859
ACKR1	CCL19	ENSCAFP00000035226	ENSCAFP00000002873	Atypical chemokine receptor 1.	C-C motif chemokine.	0.455
ACKR1	CCL2	ENSCAFP00000035226	ENSCAFP00000027107	Atypical chemokine receptor 1.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.434
ACKR4	ACKR1	ENSCAFP00000009573	ENSCAFP00000035226	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 1.	0.859
ACKR4	CCL1	ENSCAFP00000009573	ENSCAFP00000048804	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.906
ACKR4	CCL13	ENSCAFP00000009573	ENSCAFP00000032928	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.868
ACKR4	CCL19	ENSCAFP00000009573	ENSCAFP00000002873	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.984
ACKR4	CCL2	ENSCAFP00000009573	ENSCAFP00000027107	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.679
ACKR4	CCL25	ENSCAFP00000009573	ENSCAFP00000027121	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.991
ACKR4	CCL8	ENSCAFP00000009573	ENSCAFP00000027105	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).	0.933
ACKR4	CCR7	ENSCAFP00000009573	ENSCAFP00000041961	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.881
ACKR4	CCR9	ENSCAFP00000009573	ENSCAFP00000020448	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Chemokine C-C motif receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.881
ACKR4	CXCR6	ENSCAFP00000009573	ENSCAFP00000020442	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.695
CCL1	ACKR4	ENSCAFP00000048804	ENSCAFP00000009573	C-C motif chemokine.	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.906
CCL1	CCL13	ENSCAFP00000048804	ENSCAFP00000032928	C-C motif chemokine.	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.529
CCL1	CCL19	ENSCAFP00000048804	ENSCAFP00000002873	C-C motif chemokine.	C-C motif chemokine.	0.538
CCL1	CCL2	ENSCAFP00000048804	ENSCAFP00000027107	C-C motif chemokine.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.710
CCL1	CCL25	ENSCAFP00000048804	ENSCAFP00000027121	C-C motif chemokine.	C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.525
CCL1	CCL8	ENSCAFP00000048804	ENSCAFP00000027105	C-C motif chemokine.	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).	0.459
CCL1	CCR7	ENSCAFP00000048804	ENSCAFP00000041961	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.867