STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDRGK1DDRGK domain containing 1. (390 aa)    
Predicted Functional Partners:
CDK5RAP3
CDK5 regulatory subunit associated protein 3.
   
 
 0.942
UFL1
UFM1 specific ligase 1.
   
 
 0.929
UFM1
Ubiquitin fold modifier 1.
   
 
 0.723
UFC1
Ubiquitin-fold modifier conjugating enzyme 1.
   
 
 0.720
MKRN1
Uncharacterized protein.
   
  
 0.679
PCDH10
Protocadherin 10.
      
 0.650
SRPRB
SRP receptor subunit beta.
   
 
 0.650
SRP68
Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
   
 
 0.574
UBA5
Ubiquitin like modifier activating enzyme 5.
   
  
 0.564
SPRY3
Sprouty RTK signaling antagonist 3.
      
 0.563
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.