STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)    
Predicted Functional Partners:
SGMS1
Sphingomyelin synthase 1.
     
 0.965
SMPD2
Sphingomyelin phosphodiesterase 2.
     
 0.961
SGMS2
Sphingomyelin synthase 2.
     
 0.957
SMPD3
Sphingomyelin phosphodiesterase 3.
     
 0.956
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
   
 0.955
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.948
GBA
Glucosylceramidase.
   
 
 0.947
GALC
Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family.
     
 0.943
SMPD4
Sphingomyelin phosphodiesterase 4.
     
 0.940
CERS2
Ceramide synthase 2.
     
 0.933
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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