STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)    
Predicted Functional Partners:
SGMS1
Sphingomyelin synthase 1.
   
 
 0.979
SGMS2
Sphingomyelin synthase 2.
   
 
 0.973
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.966
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
   
 0.962
SMPD2
Sphingomyelin phosphodiesterase 2.
   
 
 0.961
GBA
Glucosylceramidase.
   
 
 0.957
SMPD3
Sphingomyelin phosphodiesterase 3.
     
 0.957
CERS2
Ceramide synthase 2.
   
 
 0.951
SMPD4
Sphingomyelin phosphodiesterase 4.
   
 
 0.951
CERS4
Ceramide synthase 4.
   
 
 0.950
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.