LZTS3 protein (Canis lupus familiaris) - STRING interaction network

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LZTS3

Leucine zipper tumor suppressor family member 3. (673 aa)

Predicted Functional Partners:

SHANK2

0.815

CTNNB1

0.747

LZTS1

0.721

JUP

0.537

DYRK1A

0.497

RPS16

0.497

AFDN

0.481

SIPA1L3

0.456

SIPA1L2

0.456

SIPA1

0.456

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	CTNNB1	ENSCAFP00000057828	ENSCAFP00000007783	Afadin, adherens junction formation factor.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.523
AFDN	LZTS3	ENSCAFP00000057828	ENSCAFP00000009607	Afadin, adherens junction formation factor.	Leucine zipper tumor suppressor family member 3.	0.481
AFDN	SIPA1	ENSCAFP00000057828	ENSCAFP00000019684	Afadin, adherens junction formation factor.	Signal-induced proliferation-associated 1.	0.905
AFDN	SIPA1L2	ENSCAFP00000057828	ENSCAFP00000017203	Afadin, adherens junction formation factor.	Signal induced proliferation associated 1 like 2.	0.661
AFDN	SIPA1L3	ENSCAFP00000057828	ENSCAFP00000008961	Afadin, adherens junction formation factor.	Signal induced proliferation associated 1 like 3.	0.682
CTNNB1	AFDN	ENSCAFP00000007783	ENSCAFP00000057828	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Afadin, adherens junction formation factor.	0.523
CTNNB1	JUP	ENSCAFP00000007783	ENSCAFP00000023403	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Uncharacterized protein.	0.997
CTNNB1	LZTS3	ENSCAFP00000007783	ENSCAFP00000009607	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Leucine zipper tumor suppressor family member 3.	0.747
DYRK1A	LZTS3	ENSCAFP00000014403	ENSCAFP00000009607	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Leucine zipper tumor suppressor family member 3.	0.497
DYRK1A	RPS16	ENSCAFP00000014403	ENSCAFP00000066023	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.875
JUP	CTNNB1	ENSCAFP00000023403	ENSCAFP00000007783	Uncharacterized protein.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.997
JUP	LZTS3	ENSCAFP00000023403	ENSCAFP00000009607	Uncharacterized protein.	Leucine zipper tumor suppressor family member 3.	0.537
LZTS1	LZTS3	ENSCAFP00000014785	ENSCAFP00000009607	Leucine zipper tumor suppressor 1.	Leucine zipper tumor suppressor family member 3.	0.721
LZTS1	SIPA1	ENSCAFP00000014785	ENSCAFP00000019684	Leucine zipper tumor suppressor 1.	Signal-induced proliferation-associated 1.	0.461
LZTS1	SIPA1L2	ENSCAFP00000014785	ENSCAFP00000017203	Leucine zipper tumor suppressor 1.	Signal induced proliferation associated 1 like 2.	0.735
LZTS1	SIPA1L3	ENSCAFP00000014785	ENSCAFP00000008961	Leucine zipper tumor suppressor 1.	Signal induced proliferation associated 1 like 3.	0.461
LZTS3	AFDN	ENSCAFP00000009607	ENSCAFP00000057828	Leucine zipper tumor suppressor family member 3.	Afadin, adherens junction formation factor.	0.481
LZTS3	CTNNB1	ENSCAFP00000009607	ENSCAFP00000007783	Leucine zipper tumor suppressor family member 3.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.747
LZTS3	DYRK1A	ENSCAFP00000009607	ENSCAFP00000014403	Leucine zipper tumor suppressor family member 3.	Dual specificity tyrosine phosphorylation regulated kinase 1A.	0.497
LZTS3	JUP	ENSCAFP00000009607	ENSCAFP00000023403	Leucine zipper tumor suppressor family member 3.	Uncharacterized protein.	0.537