STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RIC8ARIC8 guanine nucleotide exchange factor A. (617 aa)    
Predicted Functional Partners:
NCS1
Neuronal calcium sensor 1.
    
 
 0.856
GNAO1
G protein subunit alpha o1.
    
 
 0.821
EFEMP1
EGF containing fibulin extracellular matrix protein 1.
    
   0.744
WFS1
Wolframin ER transmembrane glycoprotein.
   
    0.724
GNAI1
G protein subunit alpha i1.
    
 
 0.722
GNAI3
G protein subunit alpha i3.
    
 
 0.722
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).
    
 
 0.722
GNA11
Uncharacterized protein.
   
 
 0.689
GNA12
G protein subunit alpha 12.
    
 
 0.683
GNA13
G protein subunit alpha 13.
    
 
 0.670
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (60%) [HD]