SIRT3 protein (Canis lupus familiaris) - STRING interaction network

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Score

SIRT3

NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)

Predicted Functional Partners:

SIRT4

0.963

NOL7

0.962

NAMPT

0.959

SIRT1

0.948

SIRT6

0.946

SARM1

0.924

CD38

0.923

NADK

0.918

NMNAT3

0.917

FOXO3

0.913

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD38	NADK	ENSCAFP00000042321	ENSCAFP00000028345	CD38 molecule.	NAD kinase.	0.928
CD38	NAMPT	ENSCAFP00000042321	ENSCAFP00000065089	CD38 molecule.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.951
CD38	NMNAT3	ENSCAFP00000042321	ENSCAFP00000059663	CD38 molecule.	Nicotinamide-nucleotide adenylyltransferase.	0.931
CD38	NOL7	ENSCAFP00000042321	ENSCAFP00000058260	CD38 molecule.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...]	0.908
CD38	SARM1	ENSCAFP00000042321	ENSCAFP00000027553	CD38 molecule.	Sterile alpha and TIR motif containing 1.	0.948
CD38	SIRT1	ENSCAFP00000042321	ENSCAFP00000019617	CD38 molecule.	Sirtuin 1.	0.933
CD38	SIRT3	ENSCAFP00000042321	ENSCAFP00000009649	CD38 molecule.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.923
CD38	SIRT4	ENSCAFP00000042321	ENSCAFP00000053475	CD38 molecule.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.908
CD38	SIRT6	ENSCAFP00000042321	ENSCAFP00000038856	CD38 molecule.	Sirtuin 6.	0.930
FOXO3	NOL7	ENSCAFP00000005627	ENSCAFP00000058260	Forkhead box O3.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...]	0.425
FOXO3	SIRT1	ENSCAFP00000005627	ENSCAFP00000019617	Forkhead box O3.	Sirtuin 1.	0.997
FOXO3	SIRT3	ENSCAFP00000005627	ENSCAFP00000009649	Forkhead box O3.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.913
FOXO3	SIRT4	ENSCAFP00000005627	ENSCAFP00000053475	Forkhead box O3.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.463
FOXO3	SIRT6	ENSCAFP00000005627	ENSCAFP00000038856	Forkhead box O3.	Sirtuin 6.	0.611
NADK	CD38	ENSCAFP00000028345	ENSCAFP00000042321	NAD kinase.	CD38 molecule.	0.928
NADK	NAMPT	ENSCAFP00000028345	ENSCAFP00000065089	NAD kinase.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.513
NADK	NMNAT3	ENSCAFP00000028345	ENSCAFP00000059663	NAD kinase.	Nicotinamide-nucleotide adenylyltransferase.	0.967
NADK	NOL7	ENSCAFP00000028345	ENSCAFP00000058260	NAD kinase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...]	0.906
NADK	SARM1	ENSCAFP00000028345	ENSCAFP00000027553	NAD kinase.	Sterile alpha and TIR motif containing 1.	0.949
NADK	SIRT1	ENSCAFP00000028345	ENSCAFP00000019617	NAD kinase.	Sirtuin 1.	0.917