STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (701 aa)    
Predicted Functional Partners:
LTC4S
Leukotriene C4 synthase.
     
 0.972
ALOX5
Arachidonate 5-lipoxygenase.
    
 0.964
ALOX5AP
Arachidonate 5-lipoxygenase activating protein.
   
  
 0.855
TRIT1
tRNA isopentenyltransferase 1; Belongs to the IPP transferase family.
 
 
    0.834
FXR1
FMR1 autosomal homolog 1.
   
  
 0.642
GFM1
Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...]
   
 
 0.587
HTR2B
5-hydroxytryptamine receptor 2B.
      
 0.576
DPEP2
Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
   
 
 0.499
DPEP3
Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
   
 
 0.497
PIK3R5
Phosphoinositide-3-kinase regulatory subunit 5.
      
 0.485
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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