STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1513 aa)    
Predicted Functional Partners:
CDC45
Cell division cycle 45.
   
 
 0.989
BARD1
BRCA1 associated RING domain 1.
   
 0.987
ATRIP
ATR interacting protein.
    
 0.983
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
   
 
 0.982
RAD9B
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.978
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.976
TP53BP1
Tumor protein p53 binding protein 1.
   
 
 0.975
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 0.971
MCM5
Minichromosome maintenance complex component 5; Belongs to the MCM family.
   
 
 0.962
MCM3
Minichromosome maintenance complex component 3; Belongs to the MCM family.
   
 
 0.961
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.