LOC483397 protein (Canis lupus familiaris) - STRING interaction network

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Score

LOC483397

Uncharacterized protein. (126 aa)

Predicted Functional Partners:

CTSB

0.743

NMRAL1

0.687

HELZ2

0.657

CTSZ

0.648

CTSO

0.620

EPSTI1

0.618

CTSH

0.609

LAMP1

0.594

BCL2

0.588

CTSA

0.587

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTSB	ENSCAFP00000000102	ENSCAFP00000059573	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Cathepsin B; Belongs to the peptidase C1 family.	0.924
BCL2	CTSH	ENSCAFP00000000102	ENSCAFP00000031547	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Cathepsin H; Belongs to the peptidase C1 family.	0.883
BCL2	CTSO	ENSCAFP00000000102	ENSCAFP00000012615	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Cathepsin O; Belongs to the peptidase C1 family.	0.881
BCL2	CTSZ	ENSCAFP00000000102	ENSCAFP00000047997	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Cathepsin Z; Belongs to the peptidase C1 family.	0.887
BCL2	LOC483397	ENSCAFP00000000102	ENSCAFP00000009710	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Uncharacterized protein.	0.588
CTSA	CTSB	ENSCAFP00000014432	ENSCAFP00000059573	Carboxypeptidase; Belongs to the peptidase S10 family.	Cathepsin B; Belongs to the peptidase C1 family.	0.949
CTSA	CTSH	ENSCAFP00000014432	ENSCAFP00000031547	Carboxypeptidase; Belongs to the peptidase S10 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.885
CTSA	CTSO	ENSCAFP00000014432	ENSCAFP00000012615	Carboxypeptidase; Belongs to the peptidase S10 family.	Cathepsin O; Belongs to the peptidase C1 family.	0.808
CTSA	CTSZ	ENSCAFP00000014432	ENSCAFP00000047997	Carboxypeptidase; Belongs to the peptidase S10 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.915
CTSA	LAMP1	ENSCAFP00000014432	ENSCAFP00000009494	Carboxypeptidase; Belongs to the peptidase S10 family.	Lysosomal associated membrane protein 1.	0.544
CTSA	LOC483397	ENSCAFP00000014432	ENSCAFP00000009710	Carboxypeptidase; Belongs to the peptidase S10 family.	Uncharacterized protein.	0.587
CTSB	BCL2	ENSCAFP00000059573	ENSCAFP00000000102	Cathepsin B; Belongs to the peptidase C1 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.924
CTSB	CTSA	ENSCAFP00000059573	ENSCAFP00000014432	Cathepsin B; Belongs to the peptidase C1 family.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.949
CTSB	CTSH	ENSCAFP00000059573	ENSCAFP00000031547	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.919
CTSB	CTSO	ENSCAFP00000059573	ENSCAFP00000012615	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin O; Belongs to the peptidase C1 family.	0.843
CTSB	CTSZ	ENSCAFP00000059573	ENSCAFP00000047997	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.914
CTSB	LAMP1	ENSCAFP00000059573	ENSCAFP00000009494	Cathepsin B; Belongs to the peptidase C1 family.	Lysosomal associated membrane protein 1.	0.908
CTSB	LOC483397	ENSCAFP00000059573	ENSCAFP00000009710	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein.	0.743
CTSH	BCL2	ENSCAFP00000031547	ENSCAFP00000000102	Cathepsin H; Belongs to the peptidase C1 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.883
CTSH	CTSA	ENSCAFP00000031547	ENSCAFP00000014432	Cathepsin H; Belongs to the peptidase C1 family.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.885