STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SIGIRRSingle Ig and TIR domain containing. (354 aa)    
Predicted Functional Partners:
TOLLIP
Toll interacting protein.
    
 
 0.695
ORAI3
F-box and leucine rich repeat protein 19.
    
 0.669
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
      
 0.591
SSR4
Signal sequence receptor subunit 4.
      
 0.591
TADA3
Transcriptional adaptor 3.
    
 
 0.547
MTHFD1L
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.
      
 0.532
IL37
Interleukin-1.
     
 0.531
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.525
MYD88
MYD88 innate immune signal transduction adaptor.
    
 0.523
IRAK3
Interleukin 1 receptor associated kinase 3.
    
 0.507
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.