STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F6Y518_CANLFIRF-3 domain-containing protein. (90 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.996
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.981
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.976
TBK1
TANK binding kinase 1.
    
 0.975
IRF3
Interferon regulatory factor 3.
   
 0.966
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.956
ZBP1
Z-DNA binding protein 1.
   
 0.949
ISG15
ISG15 ubiquitin like modifier.
   
 0.947
IRAK4
Interleukin 1 receptor associated kinase 4.
    
 0.935
CREBBP
CREB binding protein.
    
 0.912
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.