SNAI2 protein (Canis lupus familiaris) - STRING interaction network

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Score

SNAI2

Snail family transcriptional repressor 2. (268 aa)

Predicted Functional Partners:

MDM2

0.844

ENSCAFP00000058070

0.816

CDH1

0.815

TWIST2

0.757

KDM1A

0.724

BTRC

0.717

RCOR1

0.701

FBXL14

0.696

GSK3B

0.691

HMG20A

0.678

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	ENSCAFP00000058070	ENSCAFP00000014526	ENSCAFP00000058070	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Uncharacterized protein.	0.852
BTRC	FBXL14	ENSCAFP00000014526	ENSCAFP00000062618	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine rich repeat protein 14.	0.451
BTRC	GSK3B	ENSCAFP00000014526	ENSCAFP00000034412	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.814
BTRC	MDM2	ENSCAFP00000014526	ENSCAFP00000065951	Beta-transducin repeat containing E3 ubiquitin protein ligase.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.824
BTRC	SNAI2	ENSCAFP00000014526	ENSCAFP00000009921	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Snail family transcriptional repressor 2.	0.717
BTRC	TWIST2	ENSCAFP00000014526	ENSCAFP00000018365	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Twist family bHLH transcription factor 2.	0.797
CDH1	ENSCAFP00000058070	ENSCAFP00000030112	ENSCAFP00000058070	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Uncharacterized protein.	0.540
CDH1	GSK3B	ENSCAFP00000030112	ENSCAFP00000034412	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.563
CDH1	MDM2	ENSCAFP00000030112	ENSCAFP00000065951	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.898
CDH1	SNAI2	ENSCAFP00000030112	ENSCAFP00000009921	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Snail family transcriptional repressor 2.	0.815
CDH1	TWIST2	ENSCAFP00000030112	ENSCAFP00000018365	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	Twist family bHLH transcription factor 2.	0.524
ENSCAFP00000058070	BTRC	ENSCAFP00000058070	ENSCAFP00000014526	Uncharacterized protein.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.852
ENSCAFP00000058070	CDH1	ENSCAFP00000058070	ENSCAFP00000030112	Uncharacterized protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.540
ENSCAFP00000058070	SNAI2	ENSCAFP00000058070	ENSCAFP00000009921	Uncharacterized protein.	Snail family transcriptional repressor 2.	0.816
FBXL14	BTRC	ENSCAFP00000062618	ENSCAFP00000014526	F-box and leucine rich repeat protein 14.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.451
FBXL14	SNAI2	ENSCAFP00000062618	ENSCAFP00000009921	F-box and leucine rich repeat protein 14.	Snail family transcriptional repressor 2.	0.696
GSK3B	BTRC	ENSCAFP00000034412	ENSCAFP00000014526	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.814
GSK3B	CDH1	ENSCAFP00000034412	ENSCAFP00000030112	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.	0.563
GSK3B	SNAI2	ENSCAFP00000034412	ENSCAFP00000009921	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Snail family transcriptional repressor 2.	0.691
HMG20A	KDM1A	ENSCAFP00000026696	ENSCAFP00000053375	High mobility group 20A.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.941