STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNKSPoly [ADP-ribose] polymerase. (1327 aa)    
Predicted Functional Partners:
RNF146
Ring finger protein 146.
   
 
 0.985
TERF1
Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
    
 
 0.976
GMDS
GDP-mannose 4,6-dehydratase.
    
 
 0.976
TNKS2
Poly [ADP-ribose] polymerase.
  
0.972
AXIN1
Axin 1.
    
 0.966
TINF2
TERF1 interacting nuclear factor 2.
    
 0.917
AXIN2
Axin 2.
    
 0.913
BABAM1
BRISC and BRCA1 A complex member 1.
    
 
 0.871
TNKS1BP1
Tankyrase 1 binding protein 1.
    
 
 0.824
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]
   
 0.820
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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