STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1042 aa)    
Predicted Functional Partners:
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 0.924
BMI1
RING-type domain-containing protein.
   
  
 0.843
ASCL2
Achaete-scute family bHLH transcription factor 2.
   
  
 0.839
EGFR
Receptor protein-tyrosine kinase.
   
 0.808
OLFM4
Olfactomedin 4.
    
 
 0.736
HOPX
HOP homeobox.
    
 
 0.709
MSI1
Musashi RNA binding protein 1.
      
 0.676
ADGRL2
Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.
    
   0.630
ADGRL1
Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.
    
   0.630
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
    
   0.630
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.