LRIG1 protein (Canis lupus familiaris) - STRING interaction network

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Score

LRIG1

Leucine rich repeats and immunoglobulin like domains 1. (1042 aa)

Predicted Functional Partners:

EGFR

0.897

ERBB2

0.847

LRIG3

0.835

BMI1

0.832

LRIG2

0.824

ASCL2

0.817

OLFM4

0.796

GAL3ST1

0.775

RET

0.705

HOPX

0.687

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	BMI1	ENSCAFP00000014850	ENSCAFP00000050138	Achaete-scute family bHLH transcription factor 2.	RING-type domain-containing protein.	0.613
ASCL2	HOPX	ENSCAFP00000014850	ENSCAFP00000038631	Achaete-scute family bHLH transcription factor 2.	HOP homeobox.	0.561
ASCL2	LRIG1	ENSCAFP00000014850	ENSCAFP00000009972	Achaete-scute family bHLH transcription factor 2.	Leucine rich repeats and immunoglobulin like domains 1.	0.817
ASCL2	OLFM4	ENSCAFP00000014850	ENSCAFP00000034024	Achaete-scute family bHLH transcription factor 2.	Olfactomedin 4.	0.878
BMI1	ASCL2	ENSCAFP00000050138	ENSCAFP00000014850	RING-type domain-containing protein.	Achaete-scute family bHLH transcription factor 2.	0.613
BMI1	HOPX	ENSCAFP00000050138	ENSCAFP00000038631	RING-type domain-containing protein.	HOP homeobox.	0.600
BMI1	LRIG1	ENSCAFP00000050138	ENSCAFP00000009972	RING-type domain-containing protein.	Leucine rich repeats and immunoglobulin like domains 1.	0.832
BMI1	OLFM4	ENSCAFP00000050138	ENSCAFP00000034024	RING-type domain-containing protein.	Olfactomedin 4.	0.806
EGFR	ERBB2	ENSCAFP00000005164	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.994
EGFR	LRIG1	ENSCAFP00000005164	ENSCAFP00000009972	Receptor protein-tyrosine kinase.	Leucine rich repeats and immunoglobulin like domains 1.	0.897
EGFR	RET	ENSCAFP00000005164	ENSCAFP00000046537	Receptor protein-tyrosine kinase.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.949
ERBB2	EGFR	ENSCAFP00000024079	ENSCAFP00000005164	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.994
ERBB2	LRIG1	ENSCAFP00000024079	ENSCAFP00000009972	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Leucine rich repeats and immunoglobulin like domains 1.	0.847
ERBB2	LRIG2	ENSCAFP00000024079	ENSCAFP00000040363	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Leucine rich repeats and immunoglobulin like domains 2.	0.426
ERBB2	LRIG3	ENSCAFP00000024079	ENSCAFP00000062693	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Leucine rich repeats and immunoglobulin like domains 3.	0.764
ERBB2	RET	ENSCAFP00000024079	ENSCAFP00000046537	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.889
GAL3ST1	LRIG1	ENSCAFP00000037347	ENSCAFP00000009972	Galactose-3-O-sulfotransferase 1.	Leucine rich repeats and immunoglobulin like domains 1.	0.775
GAL3ST1	LRIG2	ENSCAFP00000037347	ENSCAFP00000040363	Galactose-3-O-sulfotransferase 1.	Leucine rich repeats and immunoglobulin like domains 2.	0.699
GAL3ST1	LRIG3	ENSCAFP00000037347	ENSCAFP00000062693	Galactose-3-O-sulfotransferase 1.	Leucine rich repeats and immunoglobulin like domains 3.	0.850
HOPX	ASCL2	ENSCAFP00000038631	ENSCAFP00000014850	HOP homeobox.	Achaete-scute family bHLH transcription factor 2.	0.561