PXDNL protein (Canis lupus familiaris) - STRING interaction network

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Score

PXDNL

Peroxidasin like. (1468 aa)

Predicted Functional Partners:

PCMTD1

0.843

BMS1

0.741

TH

0.711

CNIH3

0.608

CCDC42

0.608

BRSK2

0.599

ARHGEF10

0.592

CASP3

0.580

BDNF

0.577

GFAP

0.573

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF10	BRSK2	ENSCAFP00000020133	ENSCAFP00000048564	Rho guanine nucleotide exchange factor 10.	BR serine/threonine kinase 2.	0.406
ARHGEF10	CCDC42	ENSCAFP00000020133	ENSCAFP00000055300	Rho guanine nucleotide exchange factor 10.	Coiled-coil domain containing 42.	0.422
ARHGEF10	CNIH3	ENSCAFP00000020133	ENSCAFP00000024050	Rho guanine nucleotide exchange factor 10.	Cornichon family AMPA receptor auxiliary protein 3.	0.407
ARHGEF10	PCMTD1	ENSCAFP00000020133	ENSCAFP00000010064	Rho guanine nucleotide exchange factor 10.	Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1.	0.609
ARHGEF10	PXDNL	ENSCAFP00000020133	ENSCAFP00000010033	Rho guanine nucleotide exchange factor 10.	Peroxidasin like.	0.592
BDNF	CASP3	ENSCAFP00000014984	ENSCAFP00000011475	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.834
BDNF	GFAP	ENSCAFP00000014984	ENSCAFP00000058935	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.881
BDNF	PXDNL	ENSCAFP00000014984	ENSCAFP00000010033	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Peroxidasin like.	0.577
BDNF	TH	ENSCAFP00000014984	ENSCAFP00000014845	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.835
BMS1	PXDNL	ENSCAFP00000010578	ENSCAFP00000010033	BMS1 ribosome biogenesis factor.	Peroxidasin like.	0.741
BRSK2	ARHGEF10	ENSCAFP00000048564	ENSCAFP00000020133	BR serine/threonine kinase 2.	Rho guanine nucleotide exchange factor 10.	0.406
BRSK2	CCDC42	ENSCAFP00000048564	ENSCAFP00000055300	BR serine/threonine kinase 2.	Coiled-coil domain containing 42.	0.512
BRSK2	CNIH3	ENSCAFP00000048564	ENSCAFP00000024050	BR serine/threonine kinase 2.	Cornichon family AMPA receptor auxiliary protein 3.	0.474
BRSK2	PCMTD1	ENSCAFP00000048564	ENSCAFP00000010064	BR serine/threonine kinase 2.	Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1.	0.688
BRSK2	PXDNL	ENSCAFP00000048564	ENSCAFP00000010033	BR serine/threonine kinase 2.	Peroxidasin like.	0.599
CASP3	BDNF	ENSCAFP00000011475	ENSCAFP00000014984	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.834
CASP3	GFAP	ENSCAFP00000011475	ENSCAFP00000058935	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.872
CASP3	PXDNL	ENSCAFP00000011475	ENSCAFP00000010033	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Peroxidasin like.	0.580
CASP3	TH	ENSCAFP00000011475	ENSCAFP00000014845	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.794
CCDC42	ARHGEF10	ENSCAFP00000055300	ENSCAFP00000020133	Coiled-coil domain containing 42.	Rho guanine nucleotide exchange factor 10.	0.422