| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BIRC2 | BIRC3 | ENSCAFP00000022277 | ENSCAFP00000050122 | Baculoviral IAP repeat containing 2. | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | 0.903 |
| BIRC2 | IKBKG | ENSCAFP00000022277 | ENSCAFP00000028998 | Baculoviral IAP repeat containing 2. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.740 |
| BIRC2 | IRF9 | ENSCAFP00000022277 | ENSCAFP00000017662 | Baculoviral IAP repeat containing 2. | Uncharacterized protein. | 0.940 |
| BIRC2 | RBCK1 | ENSCAFP00000022277 | ENSCAFP00000010292 | Baculoviral IAP repeat containing 2. | RANBP2-type and C3HC4-type zinc finger containing 1. | 0.920 |
| BIRC2 | RIPK1 | ENSCAFP00000022277 | ENSCAFP00000013721 | Baculoviral IAP repeat containing 2. | Receptor interacting serine/threonine kinase 1. | 0.964 |
| BIRC2 | RIPK2 | ENSCAFP00000022277 | ENSCAFP00000013170 | Baculoviral IAP repeat containing 2. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.953 |
| BIRC2 | SHARPIN | ENSCAFP00000022277 | ENSCAFP00000002217 | Baculoviral IAP repeat containing 2. | SHANK associated RH domain interactor. | 0.921 |
| BIRC2 | TNF | ENSCAFP00000022277 | ENSCAFP00000000739 | Baculoviral IAP repeat containing 2. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.876 |
| BIRC2 | TNFRSF1A | ENSCAFP00000022277 | ENSCAFP00000062480 | Baculoviral IAP repeat containing 2. | TNF receptor superfamily member 1A. | 0.974 |
| BIRC2 | TRAF2 | ENSCAFP00000022277 | ENSCAFP00000028895 | Baculoviral IAP repeat containing 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.965 |
| BIRC3 | BIRC2 | ENSCAFP00000050122 | ENSCAFP00000022277 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Baculoviral IAP repeat containing 2. | 0.903 |
| BIRC3 | IKBKG | ENSCAFP00000050122 | ENSCAFP00000028998 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.740 |
| BIRC3 | IRF9 | ENSCAFP00000050122 | ENSCAFP00000017662 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Uncharacterized protein. | 0.939 |
| BIRC3 | RBCK1 | ENSCAFP00000050122 | ENSCAFP00000010292 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | RANBP2-type and C3HC4-type zinc finger containing 1. | 0.920 |
| BIRC3 | RIPK1 | ENSCAFP00000050122 | ENSCAFP00000013721 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Receptor interacting serine/threonine kinase 1. | 0.964 |
| BIRC3 | RIPK2 | ENSCAFP00000050122 | ENSCAFP00000013170 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.954 |
| BIRC3 | SHARPIN | ENSCAFP00000050122 | ENSCAFP00000002217 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | SHANK associated RH domain interactor. | 0.921 |
| BIRC3 | TNF | ENSCAFP00000050122 | ENSCAFP00000000739 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.880 |
| BIRC3 | TNFRSF1A | ENSCAFP00000050122 | ENSCAFP00000062480 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | TNF receptor superfamily member 1A. | 0.982 |
| BIRC3 | TRAF2 | ENSCAFP00000050122 | ENSCAFP00000028895 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.967 |