SP1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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[Homology]

Score

SP1

Sp1 transcription factor. (782 aa)

Predicted Functional Partners:

ESR1

0.996

EP300

0.989

CREBBP

0.982

MED1

0.978

ESR2

0.964

TBP

0.962

TP53

0.957

NCOA1

0.949

RELA

0.948

SP3

0.934

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	EP300	ENSCAFP00000036447	ENSCAFP00000001585	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	ESR1	ENSCAFP00000036447	ENSCAFP00000000624	CREB binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.978
CREBBP	ESR2	ENSCAFP00000036447	ENSCAFP00000023305	CREB binding protein.	Estrogen receptor 2.	0.794
CREBBP	MED1	ENSCAFP00000036447	ENSCAFP00000024203	CREB binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.624
CREBBP	NCOA1	ENSCAFP00000036447	ENSCAFP00000006049	CREB binding protein.	Nuclear receptor coactivator.	0.997
CREBBP	RELA	ENSCAFP00000036447	ENSCAFP00000019655	CREB binding protein.	RELA proto-oncogene, NF-kB subunit.	0.953
CREBBP	SP1	ENSCAFP00000036447	ENSCAFP00000010330	CREB binding protein.	Sp1 transcription factor.	0.982
CREBBP	SP3	ENSCAFP00000036447	ENSCAFP00000019415	CREB binding protein.	Sp3 transcription factor.	0.451
CREBBP	TBP	ENSCAFP00000036447	ENSCAFP00000065523	CREB binding protein.	TATA-box binding protein.	0.506
CREBBP	TP53	ENSCAFP00000036447	ENSCAFP00000064590	CREB binding protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.996
EP300	CREBBP	ENSCAFP00000001585	ENSCAFP00000036447	E1A binding protein p300.	CREB binding protein.	0.999
EP300	ESR1	ENSCAFP00000001585	ENSCAFP00000000624	E1A binding protein p300.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.963
EP300	ESR2	ENSCAFP00000001585	ENSCAFP00000023305	E1A binding protein p300.	Estrogen receptor 2.	0.794
EP300	NCOA1	ENSCAFP00000001585	ENSCAFP00000006049	E1A binding protein p300.	Nuclear receptor coactivator.	0.995
EP300	RELA	ENSCAFP00000001585	ENSCAFP00000019655	E1A binding protein p300.	RELA proto-oncogene, NF-kB subunit.	0.958
EP300	SP1	ENSCAFP00000001585	ENSCAFP00000010330	E1A binding protein p300.	Sp1 transcription factor.	0.989
EP300	SP3	ENSCAFP00000001585	ENSCAFP00000019415	E1A binding protein p300.	Sp3 transcription factor.	0.808
EP300	TP53	ENSCAFP00000001585	ENSCAFP00000064590	E1A binding protein p300.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.996
ESR1	CREBBP	ENSCAFP00000000624	ENSCAFP00000036447	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	CREB binding protein.	0.978
ESR1	EP300	ENSCAFP00000000624	ENSCAFP00000001585	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	E1A binding protein p300.	0.963