STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDGFRLPlatelet derived growth factor receptor like. (375 aa)    
Predicted Functional Partners:
VEGFA
Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...]
    
 
 0.707
MYCT1
MYC target 1.
   
  
 0.689
CTHRC1
Collagen triple helix repeat containing 1.
      
 0.672
ZC2HC1C
Zinc finger C2HC-type containing 1C.
    
 
 0.670
TINAGL1
Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family.
   
  
 0.652
MEDAG
Mesenteric estrogen dependent adipogenesis.
   
  
 0.602
COL8A1
Collagen type VIII alpha 1 chain.
   
  
 0.581
PAMR1
Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.
   
  
 0.567
DPYSL3
Dihydropyrimidinase like 3.
      
 0.561
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
   
 
 0.526
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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